Sexual differentiation in fishUploader: Zavier 17 days ago Subscribe 1322
The findings suggest that while SRY might regulate various pathways in the brain and other organs, premature activation of this gene can be deleterious to normal development and physiological function of these organs. The collective results from this model indicate that Sry and other sex chromosome associated genes interact with steroid hormones to affect neurobehavioral programming as evidenced by the fact that the phenotypes observed depend upon whether the animals were intact or gonadectomized. Female guinea pigs prenatally exposed to testosterone propionate during a specific developmental window had permanent rewiring of the neural circuitry and as adults, demonstrated male-pattern behaviors Phoenix et al. Epigenetic mechanisms are involved in sexual differentiation of the brain. However, the same genes might not regulate gonad sexual differentiation across all those with TSD. DNA methylation of the gonadal aromatase cyp19a promoter is involved in temperature-dependent sex ratio shifts in the European sea bass.