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Thus, in both the mother and fetus, the rise in 1,25 OH 2 D is dependent on substrate availability, in this case, 25 OH D, and is independent of calcium homeostasis [ 4 ]. Vitamin D supplementation during pregnancy: Developmental vitamin D deficiency alters MK induced hyperlocomotion in the adult rat: Author information Copyright and License information Disclaimer. Factors affecting the morbidity of vitamin D deficiency rickets and primary protection. There continues to be much debate regarding what constitutes frank deficiency, insufficiency and sufficiency. Such a paradigm shift will occur because of the mounting evidence that is being amassed to prove this point.