Can blood vessels penetrate bone

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Dysfunction or dysregulation of the bone vascular network may rest internal to the skeleton i. There was a problem with your submission. Hypoxia was shown to strongly stimulate the number and size of osteoclasts formed in cultures of mouse marrow or human peripheral blood mononuclear cells, resulting in large increases in resorption pit formation. J Bone Joint Surg Am. However, the intimate association with blood vessels raised the possibility that they could have additional fates and functions. Common regulatory factors such as parathyroid hormone or nitrates, both of which are potent vasodilators, might exert their osteogenic effects on bone via the vasculature.

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